Croda Beauty Highlights PFAS-free Peptides, Commits to Complete Portfolio Transition by 2026

Per- and polyfluoroalkyl substances (PFAS) have raised recent concerns due to their persistence in the environment and potential toxicity, spurring regulatory responses worldwide. In response, Croda Beauty highlighted its current PFAS-free peptides — a list it will continue to expand until all peptide offerings are PFAS-free.

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Improving Safety by Eliminating TFA PFAS from Manufacturing

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“By eliminating substances like TFA (trifluoroacetic acid) from our peptide synthesis processes, we prioritize both consumer safety and sustainability,” Croda Beauty explained. “Anticipating evolving regulations, we remain focused on delivering innovative solutions that uphold the highest standards of safety and efficacy.”

According to Arp, et al., in Environmental Science and Technology, “TFA belongs to the subclass of per- and polyfluoroalkyl substances (PFAS) known as ultrashort-chain perfluoroalkyl acids (PFAAs).” The authors added that currently, TFA concentrations are orders of magnitude higher than other per- and polyfluoroalkyl substances (PFAS), which is due to the material’s use as a transformation product.

Thermo Scientific described TFA as “commonly used in the manufacturing process to release synthesized peptides from solid-phase resins…[as well as] during reversed-phase HPLC purification of peptides.” The sourced added, “TFA is manufactured using acetate and fluoride as precursors, and residual levels of these compounds may be present whenever TFA is used. Residual TFA, fluoride, and to a much lesser extent, acetate are toxic and undesirable in peptides intended for preclinical and clinical studies.”

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Arp, et al., concurred:  “There are indications from mammalian toxicity studies that TFA is toxic to reproduction and that it exhibits liver toxicity,” the authors wrote, adding that while ecotoxicity data is scarce, collective trends imply that TFA “meets the criteria of a planetary boundary threat for novel entities because of increasing planetary-scale exposure.”

Croda Beauty’s Peptides: PFAS-free by 2026

According to Croda Beauty, its current PFAS-free peptides include:

• Biopeptide CL,
• Maxi-Lip,
• Bio-Bustyl PH,
• Matrixyl Synthe 6,
• Volulip,
• Silverfree,
• Biopeptide EL,
• Dermaxyl,
• Calmosensine and
• Idealift.

“We are committed to progressively expanding this list to achieve a PFAS-free status across our entire peptide range by the end of 2026,” the company announced.